HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
HBO1 plays an essential onco-factor to drive EMT and promote the immunotherapy resistance in ovarian cancer cells. Together, we reveal a critical role of HBO1 mediated epigenetic mechanism in OC progression, providing an insight into designing new therapy strategies.
Authors
- Jiaming Gu (ORCID: https://orcid.org/0000-0002-5113-4688)
- Yuchan Mai
- Xing Hu (ORCID: https://orcid.org/0000-0001-5871-0863)
- Rui Mao (ORCID: https://orcid.org/0000-0002-6737-2939)
- Yuanbin Cui
- Guangjin Pan (ORCID: https://orcid.org/0000-0002-2378-7198)
- Baoqiang Kang (ORCID: https://orcid.org/0000-0002-6676-3022)
- Huaisong Lin
- Cong Zhang (ORCID: https://orcid.org/0009-0009-7547-5119)
- Yanqi Zhang (ORCID: https://orcid.org/0000-0001-6896-8657)
- Qianyu Chen (ORCID: https://orcid.org/0000-0002-7434-504X)
- Xing Qi (ORCID: https://orcid.org/0000-0003-1349-4102)
- Jinmin Zhu
- Zhishuai Zhang (ORCID: https://orcid.org/0009-0006-0383-4811)
- Yongli Shan
- Peng Li (ORCID: https://orcid.org/0000-0002-6260-8383)
- Tiancheng Zhou
- Jingxi Huang
- Fei Li (ORCID: https://orcid.org/0000-0002-2089-7121)
Institutions
- Guangzhou Institutes of Biomedicine and Health (CN)
- University of Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1007/s13402-025-01055-8
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- China Postdoctoral Science Foundation
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- University of Chinese Academy of Sciences
- University of Chinese Academy of Sciences Education Foundation
- Science and Technology Planning Project of Guangdong Province
- Youth Innovation Promotion Association
- Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences