Exosomes delivering miR-129-5p combined with sorafenib ameliorate hepatocellular carcinoma progression via the KCTD1/HIF-1α/VEGF pathway
These results suggested that KCTD1 protects HIF-1α from degradation and activates the VEGF signaling cascade to enhance HCC progression. Therefore, KCTD1 may serve as a novel target of HCC and pave the way for an efficient combined therapy in advanced HCC.
Authors
- Wenhuan Huang (ORCID: https://orcid.org/0000-0003-1474-9373)
- Mi Ouyang (ORCID: https://orcid.org/0000-0002-9448-1938)
- Chengfeng Xun
- Xinyu Zhu (ORCID: https://orcid.org/0000-0003-2589-2300)
- Xiaofeng Ding (ORCID: https://orcid.org/0000-0003-2301-7334)
- Paul Kim-Ho Chu (ORCID: https://orcid.org/0000-0002-5581-4883)
- Li Chen (ORCID: https://orcid.org/0000-0001-7922-0599)
- Limin Li (ORCID: https://orcid.org/0000-0002-6470-757X)
- Zhiwei Li (ORCID: https://orcid.org/0000-0001-8031-6547)
- Ling Lin (ORCID: https://orcid.org/0000-0002-1963-2417)
- Liu Yang (ORCID: https://orcid.org/0000-0001-7587-312X)
- Kai Xiao (ORCID: https://orcid.org/0000-0002-3070-2789)
- Hao Zhou (ORCID: https://orcid.org/0009-0009-8675-8253)
- Chang Zhou
Institutions
- Central South University (CN)
- City University of Hong Kong (HK)
- Hunan Normal University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1007/s13402-025-01044-x
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- City University of Hong Kong
- National Natural Science Foundation of China