Improved Differentiation Towards Insulin Producing Beta-Cells Derived from Healthy Canine Pancreatic Ductal Organoids
The step-by-step differentiation protocol, mimicking pancreatic organogenesis, resulted in β-cells secreting insulin levels suitable for β-cell disease modelling. It remains to be seen if stem cells from diseased animals behave similarly.
Authors
- Flávia Cristina Matos Oliveira (ORCID: https://orcid.org/0000-0002-0341-1847)
- Louis C. Penning (ORCID: https://orcid.org/0000-0002-0880-9475)
- Bart Spee (ORCID: https://orcid.org/0000-0002-8114-0560)
- H.S. Kooistra (ORCID: https://orcid.org/0000-0002-8058-0492)
- Boyd H. T. Gouw
- Lisa van Uden (ORCID: https://orcid.org/0000-0002-8100-7444)
Institutions
- Utrecht University (NL)
- Universidade Federal Rural da Amazônia (BR)
Publication Details
- Journal
- Veterinary Sciences
- Published
- 2025-04-13
- DOI
- https://doi.org/10.3390/vetsci12040362
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01