Novel Link Between Myeloid-Specific Adenosine Deaminase 2 and CXCL10-CXCR3 Axis in Infectious ARDS
Acute respiratory distress syndrome (ARDS) is a severe complication of lung injury characterized by hyperinflammation and fibrosis. Here, we show a significant association between the monocyte-derived enzyme adenosine deaminase 2 (ADA2) and SARS-CoV-2 induced ARDS. We note an interesting link between ADA2 and the chemokine CXCL10 and its receptor CXCR3. By using published datasets of spatial transcriptomics and single-cell RNAseq, we show that ADA2 is highly expressed by inflammatory CD14<sup>+</sup>CD16<sup>+</sup> monocytes, along with profibrotic genes, in lungs affected by COVID-19. This study reveals important associations between key pathophysiological features of ARDS, linking hypoxia, infiltrative CXCR3 monocytes, and a monocyte-derived exoenzyme ADA2.
Authors
- Shilpa Tiwari‐Heckler
- Patrick Michl (ORCID: https://orcid.org/0000-0002-0401-5600)
- Ioannis S. Vlachos (ORCID: https://orcid.org/0000-0002-8849-808X)
- Uta Merle (ORCID: https://orcid.org/0000-0003-1386-3350)
- Z. Gordon Jiang (ORCID: https://orcid.org/0000-0003-0495-9940)
- Yered Pita-Juárez (ORCID: https://orcid.org/0000-0001-6992-252X)
- Lisa Vierbaum (ORCID: https://orcid.org/0000-0003-3661-6512)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-04-13
- DOI
- https://doi.org/10.3390/ijms26083678
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Infektionsforschung
- Medizinischen Fakultät Heidelberg, Universität Heidelberg