Analysis of Stereotyped B-Cell Receptor Frequencies Among Portuguese De Novo-Diagnosed Chronic Lymphocytic Leukemia Patients (PAIS Study)
The PAIS study highlighted the predominance of a heterogeneous BcR profile in Portuguese CLL patients. The higher percentage of patients with mutated <i>IGHV</i> at diagnosis supports prior findings. This study improves the characterization of the 10% of Portuguese CLL patients with major BcR stereotypes, offering healthcare providers better predictive power for disease progression and potentially impacting clinical decision making.
Authors
- José Pedro Carda (ORCID: https://orcid.org/0000-0002-8198-9812)
- Mafalda Alpoim
- Marta Gomes (ORCID: https://orcid.org/0009-0007-5234-8200)
- Rita Jaime
- Sónia Matos (ORCID: https://orcid.org/0000-0003-3902-9823)
- Rita Coutinho (ORCID: https://orcid.org/0000-0002-3028-6594)
- Ana Montalvão
- Francisca Miranda
- Inês Carvalhais (ORCID: https://orcid.org/0000-0001-6531-2492)
- João Filipe Raposo (ORCID: https://orcid.org/0000-0003-2589-7208)
- Teresa Ribeiro (ORCID: https://orcid.org/0000-0003-2487-5293)
- Joana Caldas
- Fernanda Vargas
- Tania Rohde Maia (ORCID: https://orcid.org/0009-0009-0937-4395)
- Daniela Alves (ORCID: https://orcid.org/0000-0002-5140-5468)
- Gisela Ferreira (ORCID: https://orcid.org/0000-0003-2812-1448)
- Sara Duarte (ORCID: https://orcid.org/0000-0002-7641-175X)
- Helena Silva (ORCID: https://orcid.org/0000-0002-9183-6561)
- Mariana Fernandes
- Ana Carolina Tsunoda Del Antonio
- Cátia Gaspar
Institutions
- Hospitais da Universidade de Coimbra (PT)
- Hospital de São João (PT)
- Hospital Pedro Hispano (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Centro Hospitalar de Lisboa Ocidental (PT)
- Hospital de Santo António (PT)
- Hospital São Teotónio (PT)
- Hospital da Luz (PT)
- Hospital de São Bernardo (PT)
- Hospital Braga (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- Hospital Santo António dos Capuchos (PT)
- Hospital Garcia de Orta (PT)
- Centro Hospitalar do Baixo Vouga (PT)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3390/cancers17081316
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Johnson and Johnson