IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia
IL1RAP exhibits preferential expression within NKt-AML, correlating with diminished overall survival rates and diminished responsiveness to hematopoietic stem cell transplantation. Moreover, internalization of IL1RAP presents a promising avenue for immunotherapeutic intervention.
Authors
- Albert Feghaly (ORCID: https://orcid.org/0000-0001-7929-415X)
- Marie-Ève Bordeleau
- Ossama Moujaber
- Richard Marcotte
- Nadine Mayotte (ORCID: https://orcid.org/0000-0003-1739-3106)
- Guy Sauvageau (ORCID: https://orcid.org/0000-0002-4333-7266)
- Véronique Lisi (ORCID: https://orcid.org/0000-0001-5385-4219)
- Guillaume Richard‐Carpentier (ORCID: https://orcid.org/0000-0001-6452-8814)
- Jalila Chagraoui (ORCID: https://orcid.org/0000-0002-7174-0554)
- Josée Hébert (ORCID: https://orcid.org/0000-0002-2267-1353)
- Anna N. Moraitis (ORCID: https://orcid.org/0000-0002-3416-480X)
- Banafsheh Khakipoor
- Isabel Boivin (ORCID: https://orcid.org/0000-0002-1216-3240)
- Vincent‐Philippe Lavallée (ORCID: https://orcid.org/0000-0001-9095-0066)
- Geneviève Boucher (ORCID: https://orcid.org/0000-0001-6389-9007)
- Alma Robert (ORCID: https://orcid.org/0009-0008-2655-450X)
- Patrick Gendron (ORCID: https://orcid.org/0000-0001-9829-2600)
- Philippe P. Roux (ORCID: https://orcid.org/0000-0002-5962-0250)
- Jean-François Spinella (ORCID: https://orcid.org/0000-0003-2492-2897)
- Azadeh Hajmirza
- Louis Thérêt (ORCID: https://orcid.org/0000-0001-8988-1286)
- Azer Farah
- Julie Lippens (ORCID: https://orcid.org/0000-0003-1147-0465)
- Éric Bonneil
- François Béliveau (ORCID: https://orcid.org/0000-0001-6324-2363)
- Sébastien Lemieux (ORCID: https://orcid.org/0000-0001-5477-1386)
- Éric Audemard (ORCID: https://orcid.org/0000-0002-1661-896X)
- Léo Aubert (ORCID: https://orcid.org/0000-0003-1499-0853)
- Arnaud Métois
- Pierre Thibault
Institutions
- Medical Council of Canada (CA)
- University of Toronto (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Princess Margaret Cancer Centre (CA)
- Hôpital Maisonneuve-Rosemont (CA)
- Institute for Research in Immunology and Cancer (CA)
- National Research Council Canada (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s40364-025-00769-z
- Citations
- 4
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 7.08
Funders
- Genome Canada
- Génome Québec
- Government of Canada
- Stem Cell Network
- Université de Montréal
- Canada First Research Excellence Fund
- Fondation Charles-Bruneau
- Institut de Valorisation des Données
- Alliance de recherche numérique du Canada
- CHU Sainte-Justine Foundation
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé