The Effect and Mechanism of IL-33 on Decidual Immune Cell Function at Maternal-Fetal Interface

白细胞介素-33 (IL-33)是一种与多种免疫调节过程相关的细胞因子，它在免疫调节、炎症反应以及多种疾病的发生发展过程中发挥着重要作用，亦在维持妊娠状态下的免疫稳态中扮演重要角色。母胎界面由滋养细胞、蜕膜基质细胞及蜕膜免疫细胞构成，其中蜕膜免疫细胞包括自然杀伤(NK)细胞、T细胞、B细胞、巨噬细胞、树突状细胞等。妊娠过程中，胎儿对于母体而言为同种半异体移植物，因此保持母胎界面的免疫平衡尤为重要，而本文通过研究IL-33对于蜕膜免疫细胞的影响及相关机制的研究进展，从而进一步探索了妊娠过程中母胎局部免疫平衡的维持。Interleukin-33 (IL-33) is a cytokine involved in a variety of immunomodulatory processes, which plays an important role in immune regulation, inflammation and the occurrence and development of various diseases, and also plays an important role in the maintenance of immune homeostasis during pregnancy. The maternal-fetal interface is composed of trophoblast cells, decidual stromal cells and decidual immune cells, among which decidual immune cells include natural killer (NK) cells, T cells, B cells, macrophages and dendritic cells. During pregnancy, the fetus is an allogeneic and semi-allogeneic graft from the mother, so it is particularly important to maintain the immune balance at the mother-fetus interface. In this paper, the influence of IL-33 on decidual immune cells and the related mechanisms have been studied, so as to further explore the maintenance of the local immune balance in the mother and fetus during pregnancy.