Research Advances on IL-37 in Innate Immune Responses

固有免疫是生物体防御病原微生物感染的第一道防线，在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员，是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞的功能、保护组织屏障等参与固有免疫应答环节，在多种疾病模型中表现出显著的抗炎作用，提示其可能作为炎症性疾病的潜在治疗靶点。Innate immunity serves as the first defense against pathogenic microorganisms, playing a crucial role in recognizing and eliminating pathogens as well as maintaining tissue homeostasis. IL-37, a member of the IL-1 cytokine family, is a newly discovered natural inhibitor of immune responses and inflammatory reactions. IL-37 participates in innate immune responses by regulating pathogen recognition, modulating the functions of innate immune cells, and protecting tissue barriers. It has demonstrated significant anti-inflammatory effects in various disease models, suggesting it might be a potential therapeutic target for inflammatory diseases.