Research Advances on Hand-Foot-Mouth Disease Caused by Coxsackievirus A6

柯萨奇病毒A组6型(Coxsackievirus A6, CA6)是一种常见的经呼吸道和消化道感染人体的肠道病毒，主要引起手足口病(hand-foot-mouth disease, HFMD)、疱疹性咽峡炎、心肌炎等疾病，严重者可导致神经系统受累、呼吸循环衰竭等，甚至死亡。随着肠道病毒71型(Enterovirus A71, EV71)疫苗的推广，CA6或其他肠道病毒已逐渐取代EV71和柯萨奇病毒A组16型(Coxsackievirus A16, CA16)成为手足口病致病的主要流行病原。因此，研究CA6对手足口病的早期认识及防控具有重要意义。现对CA6的分子结构、致病机制、流行病学及临床表现进行综述。Coxsackievirus A6 (CA6) is a prevalent enterovirus that infects the human body via the respiratory and gastrointestinal tracts, primarily responsible for hand-foot-mouth disease (HFMD), herpetic angina, myocarditis, and various other conditions. Severe cases may result in neurological involvement, respiratory and circulatory failure and so on, and potentially fatal outcomes. With the introduction of the Enterovirus A71 (EV71) vaccine, CA6 and other enteroviruses have increasingly supplanted EV71 and Coxsackievirus A16 (CA16) as the predominant agents of HFMD outbreaks. Consequently, research on CA6 holds significant importance for early detection and prevention of HFMD associated with CA6. This paper reviewed on the molecular structure, pathogenic mechanisms, epidemiology, clinical manifestations of CA6.