Study on the Correlation between Serum Caspase-1, IL-1<i>β</i> and Coronary Artery Disease in Hypertensive Patients

目的：探讨高血压患者血清含半胱氨酸的天冬氨酸蛋白水解酶-1 (Caspase-1)、白细胞介素-1β (IL-1β)水平与冠状动脉病变的关系。方法：选取2022年11月至2024年11月期间在包头医学院第一附属医院进行冠状动脉造影检查的高血压患者121例(高血压组)和同时段体检健康人群40例(对照组)。比较两组患者一般资料，通过酶联免疫吸附测定法检测两组血清Caspase-1、IL-1β水平，通过多元无序Logistic回归分析模型分析其对高血压患者冠状动脉病变的诊断价值。结果：与对照组相比，高血压组患者血清Caspase-1、IL-1β水平升高(P β水平高于冠状动脉粥样硬化组和造影正常组，冠状动脉粥样硬化组血清Caspase-1、IL-1β水平高于造影正常组(P β降低为冠心病及冠状动脉粥样硬化的独立保护因素(P β水平，与冠状动脉病变具有一定诊断价值，高血压病人血清Caspase-1、IL-1β水平升高与患者冠脉病变发生密切相关。Objective: To investigate the relationship between serum levels of cysteine containing aspartic acid protease-1 (Caspase-1) and interleukin-1β (IL-1β) and coronary artery disease in patients with hypertension. Method: 121 hypertensive patients (hypertensive group) and 40 healthy individuals (control group) who underwent coronary angiography at the First Affiliated Hospital of Baotou Medical College from November 2022 to November 2024 were selected. The general data of the two groups of patients were compared. Serum levels of Caspase-1 and IL-1β were measured using enzyme-linked immunosorbent assay (ELISA). The diagnostic value of these biomarkers for coronary artery lesions in hypertensive patients was analyzed through a multinomial logistic regression analysis model. Results: Compared with the control group, the levels of serum Caspase-1 and IL-1β in patients with hypertension were increased (P β in coronary artery disease group were higher than those in coronary artery atherosclerosis group and angiographic normal group, and the levels of serum Caspase-1 and IL-1β in coronary artery atherosclerosis group were higher than those in angiographic normal group (P β were independent protective factors for coronary heart disease and coronary atherosclerosis (P β in hypertensive patients have certain diagnostic value for coronary artery disease. Elevated levels of serum Caspase-1 and IL-1β in hypertensive patients are closely related to the occurrence of coronary artery disease.