Research Progress in the Clinical Efficacy and Mechanisms of ALA-PDT for Treating Lower Genital Tract Diseases in Women with HPV Infection

本文旨在对ALA-PDT (5-氨基酮戊酸光动力治疗)在治疗女性下生殖道疾病合并HPV感染中的临床疗效及作用机制进行综述。近年来，ALA-PDT因其微无创、可重复治疗、保留器官功能等优点逐渐受到临床重视。本文总结了ALA-PDT在女性下生殖道疾病合并HPV感染的治疗效果，此外结合国内外已有研究，对ALA-PDT对于肿瘤细胞增殖与凋亡、免疫微环境、肿瘤微环境的影响进行总结分析。研究表明，ALA-PDT在治疗女性下生殖道HPV感染及其相关病变中具有显著疗效，并且相较于传统治疗方式，具有保留器官结构以及功能完整性的优势。未来的研究应制定更加个体化的治疗方案，并探讨其与其他治疗方式的联合使用，以期提高临床疗效和降低疾病复发率。This article aims to review the clinical efficacy and mechanism of ALA-PDT (5-aminolevulinic acid photodynamic therapy) in the treatment of female lower reproductive tract diseases complicated with HPV infection. In recent years, ALA-PDT has been paid more and more attention in clinic because of its advantages of minimal invasion, repeatable treatment and preservation of organ function. In this paper, the therapeutic effect of ALA-PDT on female lower reproductive tract diseases complicated with HPV infection was summarized. In addition, the effects of ALA-PDT on tumor cell proliferation and apoptosis, immune microenvironment and tumor microenvironment were summarized and analyzed. Studies have shown that ALA-PDT has a significant effect in the treatment of HPV infection and related diseases in female lower reproductive tract, and compared with traditional treatment methods, it has the advantage of preserving organ structure and functional integrity. Future research should formulate more individualized treatment plans and explore their combined use with other treatment methods in order to improve clinical efficacy and reduce the recurrence rate of diseases.