The Advances in the Application of Remimazolam in Elderly Patients

随着人口的老龄化加快，老年患者手术需求逐年增加。但老年患者常常存在机体功能衰退，对麻醉和手术的耐受性较差。因此，选择合适的麻醉药物对老年患者的手术安全和术后恢复至关重要。瑞马唑仑是一种新型的苯二氮䓬类药物，具有起效快代谢快且代谢产物无活性的药理学特点，近年在老年患者麻醉中的应用研究逐渐增加。本文就瑞马唑仑的作用机制与药代动力学、对老年患者机体的影响和在老年患者中的临床应用作一综述，为其临床麻醉应用提供参考。With the accelerated aging of the population, the demand for surgical procedures among elderly patients continues to rise annually. However, elderly patients often experience age-related decline in physiological functions, demonstrating significantly reduced tolerance to both anesthesia and surgical interventions. Therefore, choosing appropriate anesthetic drugs is crucial for the surgical safety and postoperative recovery of elderly patients. Remimazolam is a new-type benzodiazepine drug, which has the pharmacological characteristics of rapid onset and metabolism, and its metabo-lites are inactive. There has been a gradual increase in research on the use of anesthesia in elderly patients in recent years. This article provides a comprehensive review of remimazolam’s mechanism of action and pharmacokinetics, its impact on the physiological systems of elderly patients, and its clinical applications in geriatric populations. The synthesis aims to offer evidence-based references for optimizing clinical anesthesia practices involving this agent.