Clinical Efficacy of 30% Supramolecular Salicylic Acid Combined with Heparin Sodium Cream (Heparin Ointment) in the Treatment of Rosacea

目的：本研究旨在评估30%超分子水杨酸联合海普林软膏在治疗玫瑰痤疮中的临床疗效。方法：选取2020年12月~2024年12月就诊于山东省泰山医院皮肤科门诊的60例玫瑰痤疮患者，采用随机数字表法分为观察组和对照组各30例。观察组：男11例，女19例，年龄(30.27 ± 7.05)岁(22~42岁)，病程(54.08 ± 20.13)个月。其中毛细血管红斑型17例，丘疹型10例，鼻赘型3例；对照组：男10例，女20例，年龄(31.21 ± 7.15)岁(21~44岁)，病程(55.12 ± 19.98)个月。两组患者毛细血管红斑型16例，丘疹型12例，鼻赘型2例；两组患者年龄、病程比较差异无统计学意义(P > 0.05)。对照组口服多西环素治疗8周，观察组在对照组的基础上外用超分子水杨酸联合肝素钠乳膏，在治疗前和治疗第2、4、8周观察两组疗效、症状评分。疗程结束后观察两组生活质量指数和安全性分析。结果：治疗2周后，观察组和对照组的总有效率分别为50.00%和10.00%；治疗4周后，两组的总有效率分别为70.00%和43.33%；治疗8周后，两组的总有效率分别为93.33%和63.33%；治疗第4、8周观察组疗效、症状评分优于对照组，差异有统计学意义(P P Objective: The aim of this study was to evaluate the clinical efficacy of 30% supramolecular salicylic acid combined with Heparin ointment in the treatment of rosacea. Methods: Sixty patients with rosacea who attended the outpatient clinic of the Department of Dermatology of Taishan Hospital in Shandong Province from December 2020 to December 2024 were selected and divided into 30 cases each in the observation group and the control group by using the randomized numerical table method. Observation group: Males: 11 cases, females: 19 cases, age (30.27 ± 7.05) years (range: 22 to 42 years), disease duration (54.08 ± 20.13) months. Among them, 17 cases were of the telangiectatic erythema type, 10 cases were of the papular type, and 3 cases were of the rhinophyma type. Control group: Males: 10 cases, females: 20 cases, age (31.21 ± 7.15) years (range: 21 to 44 years), disease duration (55.12 ± 19.98) months. In the control group, there were 16 cases of telangiectatic erythema type, 12 cases of papular type, and 2 cases of rhinophyma type. There was no significant difference in age and disease duration between the two groups (P > 0.05). The control group was treated with doxycycline orally for 8 weeks, and the observation group was treated with supramolecular salicylic acid combined with heparin sodium cream externally on the basis of the control group. The efficacy of treatment and the symptom scores of the two groups were observed before the treatment and in the 2nd, 4th, and 8th weeks of the treatment. The quality of life index and safety analysis of the two groups were observed at the end of the treatment. Results: After 2 weeks of treatment, the total effective rates of the observation group and the control group were 50.00% and 10.00%, respectively; after 4 weeks of treatment, the total effective rates of the two groups were 70.00% and 43.33%, respectively; after 8 weeks of treatment, the total effective rates of the two groups were 93.33% and 63.33%, respectively; At weeks 4 and 8 of treatment, the observation group showed significantly better therapeutic efficacy and symptom scores compared to the control group, with statistically significant differences (P P < 0.05); the observation group was better than the control group in terms of quality of life index and safety analysis at the end of the treatment course. In the course of treatment, 4 cases of facial dryness, 3 cases of facial flaking and tightness, 2 cases of gastrointestinal discomfort, 1 case of tingling and burning sensation, and 1 case of facial swelling, given symptomatic treatment, were improved. Conclusion: Supramolecular salicylic acid combined with Heparin ointment treatment is fast and effective, with little adverse effects, which helps to improve rosacea, and improves the quality of life of patients.