Molecular and metabolic effects of chronic stress on health, aging and carcinogenesis

MoleculAr And MeTAbolic effecTs of chronic sTress on heAlTh, AGinG And cArcinoGenesisChronic stress in modern society has many facets and sources of origin.The war in Ukraine, for instance, is a significant source of stress that could have adverse health consequences.Chronic stress has been shown to exert a multilevel, long-term, and delayed impact on health, aging, and the development of age-related diseases, including cancer.This mini-review briefly discusses a total landscape of the main aspects and directions of chronic stress, starting with the genetic and epigenetic factors that have been studied in this context.The general metabolic aspects and the effect of chronic stress on individual organs, body systems, and the role of lifestyle factors and their correction to eliminate the effects of stress and prevent the development of age-related and stress-related diseases are considered.