Long‐term outcomes of active surveillance for Grade Group 1 prostate cancer and the impact of the use of MRI on overtreatment
Our study confirms the safety of AS for GG1 PCa, with low metastasis and PCSM rates over 15 years. Furthermore, the inclusion of MRI in AS prompts increased detection of GG2, leading to increased treatment rates despite similar short-term risks. To minimise overtreatment, expanding eligibility for AS and the uptake of AS in men with favourable GG2 PCa is crucial to address the stage shift resulting from the increased accuracy of MRI.
Authors
- F. Badenchini
- Markus Graefen (ORCID: https://orcid.org/0000-0003-3609-3512)
- C. Marenghi (ORCID: https://orcid.org/0000-0002-6867-7646)
- Sebastiaan Remmers (ORCID: https://orcid.org/0000-0001-9530-6448)
- Antti Rannikko (ORCID: https://orcid.org/0000-0002-4261-3484)
- Monique J. Roobol (ORCID: https://orcid.org/0000-0001-6967-1708)
- Diederik M. Somford (ORCID: https://orcid.org/0000-0002-5277-6586)
- Mark Frydenberg (ORCID: https://orcid.org/0000-0003-4445-3573)
- Ivo I. de Vos (ORCID: https://orcid.org/0000-0001-9000-7457)
- Mikio Sugimoto (ORCID: https://orcid.org/0000-0001-9266-782X)
- Egbert R. Boevé
- Takuma Kato
- Chris H. Bangma
- Frédéric Staerman
- F. Lozano-Urunuela
Institutions
- University of Helsinki (FI)
- Kagawa University (JP)
- Helsinki University Hospital (FI)
- Sint Franciscus Gasthuis (NL)
- Cabrini Hospital (AU)
- Saint Laurent Polyclinique (FR)
- Martini-Klinik (DE)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Erasmus MC Cancer Institute (NL)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Monash University (AU)
Publication Details
- Journal
- British Journal of Urology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1111/bju.16727
- Citations
- 4
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Jane ja Aatos Erkon Säätiö
- Stichting Wetenschappelijk Onderzoek Prostaatkanker