Identification of <scp> <i>BHLHE40</i> </scp> ‐Expressing <scp>CD4</scp> <sup>+</sup> T Cells Producing <scp>GM</scp> ‐ <scp>CSF</scp> in Rheumatoid Arthritis
We analyzed the gene expressions of BHLHE40, which is crucial for GM-CSF production, IL1R1, which regulates BHLHE40 induction, and CSF2, its resulting product, in CD4<sup>+</sup> T cells. Their expression levels were compared across RA SF, PB, and HC. Notably, increased expression of these genes was identified in SF.
Authors
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Katsuya Suzuki (ORCID: https://orcid.org/0009-0008-2930-5365)
- Sho Ishigaki (ORCID: https://orcid.org/0009-0001-3100-9011)
- Masaru Takeshita (ORCID: https://orcid.org/0000-0002-3281-6595)
Institutions
- Keio University (JP)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/1756-185x.70219
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80