Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis
Trough or peak colchicine concentrations are not associated with gout flare prophylaxis efficacy. There is no consistent relationship between colchicine concentrations and colchicine-specific adverse events. Although colchicine concentrations increase with concomitant statin use, this does not result in muscle-related adverse events. These findings indicate that colchicine therapeutic drug monitoring is of limited value in clinical practice.
Authors
- Jill Drake
- Borislav Mihov (ORCID: https://orcid.org/0000-0002-0147-0595)
- Janine Haslett
- Anne Horne (ORCID: https://orcid.org/0000-0003-2783-7452)
- Lisa K. Stamp (ORCID: https://orcid.org/0000-0003-0138-2912)
- Daniel F. B. Wright (ORCID: https://orcid.org/0000-0001-9313-9252)
- Nicola Dalbeth (ORCID: https://orcid.org/0000-0003-4632-4476)
- Peter Chapman
- Christopher Frampton
Institutions
- The University of Sydney (AU)
- University of Auckland (NZ)
- Government of New Zealand (NZ)
- Auckland University of Technology (NZ)
- St Vincent's Hospital Sydney (AU)
- St Vincent’s Private Hospital Sydney (AU)
- Auckland District Health Board (NZ)
- St Vincent's Clinic (AU)
- University of Otago (NZ)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/acr.25548
- Citations
- 4
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 5.72