<scp>DREADDs</scp>‐Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons
It is feasible to apply the DREADDs-based chemogenetic tools to the ENS. Gi-DREADDs can selectively modulate the ENS, inducing STC without excitatory-neural bias, offering targeted neuromodulation for gastrointestinal motility disorders.
Authors
- Yu Wen
- Shujuan Zhou (ORCID: https://orcid.org/0000-0003-3809-7613)
- Hui Guo (ORCID: https://orcid.org/0000-0003-4725-4406)
- Nina Zhang (ORCID: https://orcid.org/0000-0002-6857-1091)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0381-0773)
- Qi Zhang (ORCID: https://orcid.org/0000-0003-2205-5857)
- Xiaotong Lu (ORCID: https://orcid.org/0000-0001-6926-9022)
- Tian Yang
- Liang Shi (ORCID: https://orcid.org/0009-0009-6058-4785)
- Ni Jiang (ORCID: https://orcid.org/0009-0007-5791-2042)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Digestive Diseases
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/1751-2980.13344
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Natural Science Foundation of Jiangsu Province