Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

This study underscores the significance of integrating genomic insights with pharmacogenomic strategies to address disparities in thyroid cancer treatment. The identification of population-specific oncogenic variants and actionable therapeutic targets provides a foundation for advancing precision oncology. Future efforts should focus on including underrepresented populations, developing population-specific prevention strategies, and fostering global collaboration to ensure equitable access to pharmacogenomic testing and innovative therapies. These initiatives have the potential to transform thyroid cancer care and align with the broader goals of personalized medicine.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-04-14
DOI
https://doi.org/10.3389/fphar.2025.1524623
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
0.00
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Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

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BRCA gene mutations in cancer
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Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

Gabriela Echeverría‐Garcés, Andrés López‐Cortés, Sebastián Rivera-Orellana, Samantha Espinoza-Ferrao, José Bueno‐Miño, Emilia Castellanos-Molina, Melanie Benítez-Núñez
article en

Abstract

This study underscores the significance of integrating genomic insights with pharmacogenomic strategies to address disparities in thyroid cancer treatment. The identification of population-specific oncogenic variants and actionable therapeutic targets provides a foundation for advancing precision oncology. Future efforts should focus on including underrepresented populations, developing population-specific prevention strategies, and fostering global collaboration to ensure equitable access to pharmacogenomic testing and innovative therapies. These initiatives have the potential to transform thyroid cancer care and align with the broader goals of personalized medicine.

Frontiers in PharmacologyVol. 16
Universidad de Las Américas (EC), Instituto Nacional de Investigación en Salud Pública (EC)
Good health and well-being
Openalex Percentile: Top 91%
BRCA gene mutations in cancer
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