Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting
This study reveals that AZD6738 demonstrates significant therapeutic efficacy by targeting the key molecule EZH2, thereby modulating the tumor microenvironment and enhancing anti-tumor immunity.
Authors
- Ya Zheng
- R.H. Li (ORCID: https://orcid.org/0009-0000-7162-373X)
- Yong‐Ning Zhou (ORCID: https://orcid.org/0000-0002-9791-3468)
- Guozhi Wu (ORCID: https://orcid.org/0000-0002-1223-1653)
- Yuping Wang (ORCID: https://orcid.org/0000-0003-0087-4771)
- Wenwen Yang (ORCID: https://orcid.org/0009-0003-1529-2296)
- Huiyun Zhang (ORCID: https://orcid.org/0000-0002-2686-2472)
- Xiangming Fang (ORCID: https://orcid.org/0000-0003-2961-0809)
- Hanxun Yue (ORCID: https://orcid.org/0009-0003-4310-7000)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s508709
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81