Treatment effect of intravenous high-dose selenium in sepsis phenotypes: a retrospective analysis of a large multicenter randomized controlled trial
Application of the four sepsis phenotypes to the SISPCT study cohort showed discrete but non-significant mortality differences within 28 days. However, beneficial treatment effects of high-dose intravenous selenium were still not detectable after categorizing the SISPCT study cohort according to four phenotype criteria.
Authors
- Patrick Meybohm (ORCID: https://orcid.org/0000-0002-2666-8696)
- Holger Bogatsch
- Christian Stoppe (ORCID: https://orcid.org/0000-0002-2028-2039)
- Frank Bloos (ORCID: https://orcid.org/0000-0002-0767-7941)
- Anna Lulu Homayr
- Christoph Engel (ORCID: https://orcid.org/0000-0002-7247-282X)
- David I. Radke
- Matthias Lindner (ORCID: https://orcid.org/0000-0003-2647-7790)
- Michael W Bauer (ORCID: https://orcid.org/0000-0002-1521-3514)
- Gunnar Elke (ORCID: https://orcid.org/0000-0002-4948-1605)
Institutions
- University Hospital Schleswig-Holstein (DE)
- Universitätsklinikum Würzburg (DE)
- Jena University Hospital (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Leipzig University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s40560-025-00790-2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- South East Physics Network