Effects of <i>Dictyophora</i> polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model
These findings indicated that DIPs might diminish EtOH-induced cerebellar degeneration and behavioral deficits through the NLRP3-ASC-caspase-1 signaling pathway, which provides a potential therapeutic target for the prevention and treatment of alcoholism and EtOH-induced cerebellar pathology.
Authors
- Baofei Sun (ORCID: https://orcid.org/0000-0002-7003-6119)
- Jiuyang Ding (ORCID: https://orcid.org/0000-0001-9089-1756)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7217-0111)
- Huanhuan Yu
- Zhihui Dai
- Yuanhe Wang
Institutions
- Guiyang Medical University (CN)
- Guizhou University (CN)
- Chinese Academy of Sciences (CN)
- Institute of Geochemistry (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1002/ame2.70021
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China