The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation
Our study demonstrates that the LysoPS/GPR174 axis, through the cAMP-PKA-CREB pathway, plays a crucial role in promoting the invasion and metastasis of ESCC. This highlights its potential as a novel target for predicting ESCC progression and may offer new insights for the development of targeted therapies for this deadly disease.
Authors
- Xueqiong Zhu (ORCID: https://orcid.org/0000-0002-8389-928X)
- Shuangfen Tao
- Zhuowei Feng
- Xiangyuan Li (ORCID: https://orcid.org/0000-0003-2201-0536)
- Xu Pei (ORCID: https://orcid.org/0000-0002-3011-9331)
- Feng Shen (ORCID: https://orcid.org/0000-0002-8904-9745)
- Meiling Zhu (ORCID: https://orcid.org/0000-0003-3798-5547)
- Fang-Bao Ding
- Yu‐Dong Cai (ORCID: https://orcid.org/0000-0001-5664-7979)
- Zhiyi Liu (ORCID: https://orcid.org/0000-0002-8122-8474)
- Haibo Xiao (ORCID: https://orcid.org/0009-0002-0520-0805)
- Rong Xiao (ORCID: https://orcid.org/0009-0003-7457-7515)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s12967-025-06419-0
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China