GLUT-Targeted Adhesive Nanoparticles Enhance the Oral Absorption and Anti-Tumor Effects of 2-Methoxyestradiol
Compared with 2-ME-NPs, 2-ME-CMZ <sub>(1:1:9)</sub>-NPs significantly enhanced absorption through the mediation of multiple subtypes of GLUT, enhancing their original cellular uptake pathway and prolonging absorption time. These findings demonstrated that 2-ME-CMZ <sub>(1:1:9)</sub>-NPs are an extremely promising oral drug delivery system for 2-ME, and endowing GLUT-targeted drug-loaded nanoparticles with adhesion is an effective strategy for fully leveraging the role of GLUT in mediating oral absorption.
Authors
- Wentao Hu (ORCID: https://orcid.org/0000-0001-8495-4175)
- Yabing Xing (ORCID: https://orcid.org/0000-0002-0627-4091)
- Yuxin Li (ORCID: https://orcid.org/0000-0001-9739-9860)
- Yulu Zhang (ORCID: https://orcid.org/0000-0003-4178-0368)
- Xinhong Guo (ORCID: https://orcid.org/0009-0007-4038-6429)
- Yuru Zhang (ORCID: https://orcid.org/0000-0003-2054-2483)
- Binghua Wang
Institutions
- Henan University of Technology (CN)
- Zhengzhou University (CN)
- Zhengzhou Children's Hospital (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s506086
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00