Exendin-4(1-32)K-Capric Acid, a Glucagon-Like Peptide-1 Receptor Agonist, Suppresses Food Intake via Arcuate Pro-Opiomelanocortin Neurons
Our results demonstrate that the appetite-suppressing effects of Ex-4c are mediated through the activation of arcuate POMC neurons. Furthermore, the PKA-dependent closure of putative KATP conductance is identified as the cellular mechanism responsible for the activation of POMC neurons.
Authors
- Jae Il Kim (ORCID: https://orcid.org/0000-0003-1668-3910)
- Jong‐Woo Sohn (ORCID: https://orcid.org/0000-0002-2840-4176)
- Eun-Seon Yoo (ORCID: https://orcid.org/0000-0002-2401-0620)
- S.B. Yoo
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Gwangju Institute of Science and Technology (KR)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3803/enm.2024.2185
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 1.83
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea