The Effect of Gambir Leaf Tea (Uncaria gambir Roxb) on Superoxide Dismutase in Diabetic Model Rats

Diabetes mellitus causes dangerous conditions due to hyperglycemia toxicity. Hyperglycemia in diabetes produces reactive oxygen species (ROS) that can deactivate the antioxidant system, leading to oxidative stress. This research aims to examine the effect of gambir leaf tea on superoxide dismutase levels in a diabetic rat model. This research is an experimental study with a post-test only control group design using 36 rats divided into six groups: K(-) received a standard diet and aquadest, K(+) was induced with alloxan, K MET received metformin, and those given gambir leaf (Uncaria gambir Roxb.) P1 (1 g/100 ml), P2 (2 g/100 ml), and P3 (4 g/100 ml) for 30 days. The SOD level was measured using an ELISA reader. Data were analyzed using Kruskal-Wallis and Post Hoc Mann-Whitney. The research results indicate that there is no significant effect of administering gambir leaf on the increase of SOD levels (p>0.05). Keywords: Diabetes Mellitus, Hyperglycemia, Superoxide Dismutase Levels, Gambir Leaf Tea.