Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition
We show that oral administration of mirabegron significantly increases the expression of uncoupling protein 1 in brown adipose tissue and β3-Adrenergic receptor protein in perigonadal white adipose and liver tissues. Furthermore, mirabegron treatment changes the relative abundance of several genus and families of rat faecal microbiota, albeit without restoring the global biodiversity and evenness indexes observed in control rats, as well as faecal bile acids composition. These changes are probably due to a direct effect of mirabegron on the gut microbiome, rather than being mediated by changes in bile acid induced by drug treatment.
Authors
- Manuel Bernabeu (ORCID: https://orcid.org/0000-0002-3011-5373)
- Juan C. Laguna (ORCID: https://orcid.org/0000-0002-7082-0704)
- Roger Bentanachs (ORCID: https://orcid.org/0000-0002-9714-163X)
- Anna Pérez‐Bosque (ORCID: https://orcid.org/0000-0003-2175-9684)
- Rosa María Galán Sánchez
- Lluïsa Miró
- Patricia Ramírez-Carrasco
- Concepció Amat
- Marta Alegret
- Núria Roglans
Institutions
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Barcelona Biomedical Research Park (ES)
- Instituto de Agroquímica y Tecnología de Alimentos (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fphar.2025.1547749
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Indian National Science Academy
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Generalitat de Catalunya
- Universitat de Barcelona
- Agencia Estatal de Investigación