Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway
Wogonin exerts protective effects against cardiac dysfunction and fibrosis in PF mice by modulating Sirt1/γ-H2AX-mediated pathways to reduce DNA damage and apoptosis. These findings suggest the potential of wogonin as a therapeutic agent for managing HF associated with PF.
Authors
- Runran Miao (ORCID: https://orcid.org/0000-0001-9437-3323)
- Lin Yang (ORCID: https://orcid.org/0000-0001-8746-9255)
- Fei Lin
- Yuan Liu (ORCID: https://orcid.org/0000-0003-2668-0350)
- Min Zhang (ORCID: https://orcid.org/0000-0003-1657-1337)
- Libo Wang (ORCID: https://orcid.org/0009-0006-2363-6476)
- Tianhao Zhao
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Henan Normal University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fphar.2025.1551141
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Xinxiang Medical University