Bleomycin-loaded folic acid-conjugated nanoliposomes: a novel formulation for targeted treatment of oral cancer
The findings suggest that FL-Bleomycin is a potential method for delivering drugs precisely in tumors expressing folic acid receptors. Its potential for successful cancer treatment is shown by its higher internalization, improved cytotoxicity, and cell cycle prevention in CAL 27 cells. To find out how effective FL-Bleomycin is <i>in vivo</i> and whether it may be used to treat other FR-expressing tumors, more research is necessary.
Authors
- Andrej Jenča (ORCID: https://orcid.org/0000-0002-9297-9134)
- Janka Jenčová (ORCID: https://orcid.org/0009-0007-4431-3227)
- Meysam Ebrahimifar
- Hadi Zare‐Zardini (ORCID: https://orcid.org/0000-0002-1501-2560)
- Elham Saberian (ORCID: https://orcid.org/0000-0002-0590-9489)
- Adriána Petrášová (ORCID: https://orcid.org/0000-0002-4289-7691)
- Andrej Jenča (ORCID: https://orcid.org/0000-0003-4501-7407)
- Mohammadreza Allahyartorkaman
- Fateme Salehipoor
- Peter Džupa
Institutions
- Slovak Medical University (SK)
- National Taiwan University (TW)
- University of Pavol Jozef Šafárik (SK)
- Mofid University (IR)
- Islamic Azad University of Shahreza (IR)
- Islamic Azad University of Najafabad (IR)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fbioe.2025.1535793
- Citations
- 4
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 3.22