Distinct blood and oral microbiome profiles reveal altered microbial composition and functional pathways in myocardial infarction patients
Our study demonstrates that the blood harbors a distinct microbiome characterized by specific microbial taxa and functional pathways rather than merely reflecting oral bacterial translocation. These findings suggest that the circulating microbiome may play an active role in the pathology of MI. Furthermore, we identified significant associations between these microbial signatures and clinical disease markers. This highlights the potential importance of the blood microbiome in understanding the mechanisms underlying MI and its diagnostic or therapeutic implications.
Authors
- Jianye Zhou (ORCID: https://orcid.org/0000-0001-7959-3539)
- Ikram Khan (ORCID: https://orcid.org/0000-0002-5233-1480)
- Tuo Chen (ORCID: https://orcid.org/0000-0002-6551-4091)
- Linghong Zhu
- Xu Zhang (ORCID: https://orcid.org/0000-0003-3492-4618)
- Xiaodong Xie (ORCID: https://orcid.org/0000-0002-9088-8167)
- Zilong Zhang (ORCID: https://orcid.org/0000-0002-3287-0436)
- Sen Lei (ORCID: https://orcid.org/0000-0001-7197-672X)
Institutions
- Minzu University of China (CN)
- Chinese Academy of Sciences (CN)
- Northwest Institute of Eco-Environment and Resources (CN)
- Gansu Provincial Hospital (CN)
- The Military General Hospital of Beijing PLA (CN)
- Qinghai Provincial Peoples Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1506382
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Gansu Province
- Fundamental Research Funds for the Central Universities