Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study
A TMA in combination with 4-plex immunofluorescence is suitable for immune cell characterization in different oral diseases. Macrophage infiltration and polarization in precursor lesions seems to be associated with OSCC development as well as metastatic spread. IL-23 pathway inhibition might be a potential target for oral Lichen and Leukoplakia.
Authors
- Carol Geppert
- Abbas Agaimy (ORCID: https://orcid.org/0000-0002-0445-8161)
- Marco Rainer Kesting (ORCID: https://orcid.org/0000-0003-4317-6834)
- Manuel Weber (ORCID: https://orcid.org/0000-0002-8649-5977)
- Kerstin M. Galler (ORCID: https://orcid.org/0009-0001-6589-0708)
- Leah Trumet (ORCID: https://orcid.org/0009-0003-2346-5206)
- Bettina Grötsch (ORCID: https://orcid.org/0000-0003-3067-6100)
- Jutta Ries (ORCID: https://orcid.org/0000-0001-5778-2742)
- Linus Winter
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1569490
- Citations
- 2
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.93