Comparison of immunotherapy based total neoadjuvant therapy or standard neoadjuvant chemoradiation for locally advanced rectal cancer: a multi-institutional retrospective study
Overall, ICIs + TNT demonstrated therapeutic efficacy and a safety profile comparable to ICIs + nCRT in patients with LARC and MSS/pMMR status. Although ICIs + TNT achieved numerically higher downstaging rates, it was not associated with improved survival outcomes. These findings underscore the importance of refining patient selection criteria and making judicious treatment decisions to enhance the prognosis of individuals with rectal cancer.
Authors
- Dingchang Li (ORCID: https://orcid.org/0000-0001-8602-2961)
- Wenxing Gao (ORCID: https://orcid.org/0000-0002-1740-8227)
- Jitao Du
- Xu Sun (ORCID: https://orcid.org/0009-0005-6435-6481)
- Zhengyao Chang (ORCID: https://orcid.org/0000-0003-4136-3003)
- Peng Chen (ORCID: https://orcid.org/0000-0002-1277-0358)
- Hanqing Jiao
- Yingjie Zhao (ORCID: https://orcid.org/0000-0001-7170-2403)
- Zhao Wen (ORCID: https://orcid.org/0000-0002-2231-8592)
- Guanglong Dong (ORCID: https://orcid.org/0000-0002-2670-0609)
- Xiangbin Wan
- Xianqiang Liu (ORCID: https://orcid.org/0009-0006-7094-2177)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Henan Cancer Hospital (CN)
- PLA Academy of Military Science (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1513716
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00