Development and validation of novel models based on clonality immunoglobulin gene rearrangement for evaluation of bone marrow involvement and prognostic prediction in patients with diffuse large B-cell Lymphoma: a multicenter retrospective study
Our results suggest that IGR is the most valuable methods for evaluating BMI compared to traditional detection methods. Adding the combination of IGR and BMB to the IPI and NCCN-IPI score may improve their predictive ability. In summary, IGR is essental for evaluation of BMI and provide an ideal method for disease staging and risk stratification in DLBCL patients in the rituximab era.
Authors
- Linhui Hu (ORCID: https://orcid.org/0000-0002-1990-4523)
- Shenghui Zhang (ORCID: https://orcid.org/0000-0002-9796-0184)
- Yangyang Ding (ORCID: https://orcid.org/0000-0003-1588-2571)
- Lianfang Pu (ORCID: https://orcid.org/0000-0003-0795-8396)
- Qianping Li (ORCID: https://orcid.org/0000-0001-7848-8622)
- Ya Liao
- Ruiqi Liu (ORCID: https://orcid.org/0000-0002-2099-620X)
- Zelin Liu (ORCID: https://orcid.org/0000-0002-8098-4235)
- Shudao Xiong (ORCID: https://orcid.org/0000-0001-5560-1936)
- Chunhua Zhu
Institutions
- Anhui Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- United States Air Force (US)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1547056
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University