Plasma Insulin-Like Growth Factor-Binding Protein-2 Levels Predict Severe Septic Acute Kidney Injury: A Mendelian Randomization Analysis

Plasma IGFBP-2 levels can predict the occurrence of SA-AKI in sepsis patients. However, MR analysis suggests that there is no direct causal relationship between plasma IGFBP-2 levels and septic kidney injury, and the underlying mechanisms need to be further investigated in randomized controlled trials.