Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations
Chemo- and site-selective functionalization of complex molecules poses a fundamental challenge. Herein, we introduce a resource-economic photoelectrocatalysis strategy to enable versatile direct fluoroalkylations catalyzed by Earth-abundant iron and paired with the hydrogen evolution reaction (HER). Notably, the devised approach proved amenable to versatile late-stage C─H fluoroalkylations of bio-relevant heterocycles, such as xanthines, nucleobases, and nucleosides. Mechanistic studies supported a ligand-to-metal charge transfer-induced formation of the fluoroalkyl radical.
Authors
- Vladimir Motornov (ORCID: https://orcid.org/0000-0002-4951-8113)
- Tristan von Münchow (ORCID: https://orcid.org/0000-0002-8911-6733)
- Claudia Stückl
- Lutz Ackermann (ORCID: https://orcid.org/0000-0001-7034-8772)
- Sven Trienes (ORCID: https://orcid.org/0009-0008-8910-7459)
- Simonetta Resta
- João C. A. Oliveira (ORCID: https://orcid.org/0000-0002-2990-0315)
- Zhipeng Lin (ORCID: https://orcid.org/0000-0003-1883-4874)
- Zhi Liu (ORCID: https://orcid.org/0009-0000-0998-9546)
Institutions
- German Centre for Cardiovascular Research (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/anie.202504143
- Citations
- 14
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 11.07
Funders
- Alexander von Humboldt-Stiftung
- Deutsches Zentrum für Herz-Kreislaufforschung
- Università degli Studi di Milano
- Deutsche Forschungsgemeinschaft
- Georg-August-Universität Göttingen
- Gottfried Wilhelm Leibniz Universität Hannover
- Leibniz-Gemeinschaft
- Erasmus+