TET2 gene mutation status associated with poor prognosis of transition zone prostate cancer: a retrospective cohort study based on whole exome sequencing and machine learning models
Our study elucidated the distinct genetic basis of prostate cancer in the transition zone and identified TET2 mutation as an independent prognostic determinant in TZ PCa. However, the limited sample size of this study necessitates cautious interpretation of these findings, and further validation in larger cohorts is warranted to confirm their generalizability.
Authors
- Ailing Yu (ORCID: https://orcid.org/0000-0001-7003-2209)
- Xiaoying Yuan (ORCID: https://orcid.org/0000-0003-1210-5654)
- Shuang Wen
- Xiaochen Du (ORCID: https://orcid.org/0000-0003-1204-2665)
- Gao Zi-ping
- Liang Wang (ORCID: https://orcid.org/0000-0002-9364-8572)
- Yutong Wang (ORCID: https://orcid.org/0000-0001-8943-1832)
- Bo Fan (ORCID: https://orcid.org/0009-0003-2945-7733)
- Zhiyu Liu (ORCID: https://orcid.org/0009-0005-7829-1797)
- Hongming Guan (ORCID: https://orcid.org/0000-0002-1466-4305)
- Peng Shi (ORCID: https://orcid.org/0000-0002-0187-7520)
- Honglong Wang (ORCID: https://orcid.org/0000-0001-5471-4445)
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Yili Friendship Hospital (CN)
- Dalian Municipal Central Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fendo.2025.1568665
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- Dalian University of Technology
- Dalian Medical University
- Dalian Institute of Chemical Physics