Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study
This study demonstrates a significant dose-response relationship between the UHR and CKD in Chinese patients with T2DM, highlighting UHR as a promising biomarker for CKD risk assessment. The identified UHR cut-off of 12.28 offers a practical threshold for early renal monitoring and targeted interventions. Future research should explore UHR-targeted therapies and its integration into personalized risk stratification models to improve CKD management in T2DM.
Authors
- Jieming Zhong (ORCID: https://orcid.org/0000-0001-8987-2216)
- Feng Lü (ORCID: https://orcid.org/0000-0002-0732-8522)
- Weiyuan Yao (ORCID: https://orcid.org/0000-0003-2786-6819)
- Ruying Hu (ORCID: https://orcid.org/0000-0002-6920-0524)
- Xiaofu Du
- Chunxiao Xu (ORCID: https://orcid.org/0000-0003-3592-7423)
- Xiangyu Chen (ORCID: https://orcid.org/0000-0002-3621-0830)
- Meng Wang (ORCID: https://orcid.org/0000-0003-2345-6740)
- Jie Zhang (ORCID: https://orcid.org/0000-0003-1363-3264)
- Lijin Chen (ORCID: https://orcid.org/0000-0002-1125-7624)
- Zhimin Ma (ORCID: https://orcid.org/0000-0002-4264-4504)
- Mingbin Liang
Institutions
- Zhejiang Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fnut.2025.1582495
- Citations
- 7
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- National Science and Technology Major Project
- Centers for Disease Control and Prevention