Phytochemical Investigation and Biological Evaluation of <i>Disynaphia filifolia</i> : A Novel Source of Tremetone in Asteraceae
Chemical investigation of Disynaphia filifolia (Hassl.) R.M. King & H. Rob. (Asteraceae) led to the isolation of eight compounds, with tremetone being the major metabolite recovered. Tremetone has been suggested as the toxic compound in Ageratina altissima and Isocoma pluriflora, two species of the Asteraceae family. Although D. filifolia is not classified as a toxic species, tremetone was identified as the major compound in the crude extract of this species, constituting approximately 21% of the total content. Furthermore, 22 compounds were annotated using dereplication techniques, ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry, and a molecular networking approach. Antiproliferative assays indicated that tremetone was weakly active against the human tumor cell lines tested, proving to be even more toxic to non-tumor cells compared to tumor cell lines. Moreover, the potential antioxidant and antibacterial activities of the crude extract and fractions of D. filifolia are reported herein.
Authors
- Drielli Rhiane P. Colhado Arêas (ORCID: https://orcid.org/0000-0002-9009-3022)
- Tatiana Shioji Tiuman (ORCID: https://orcid.org/0000-0002-7700-3459)
- Alana Carla Battistella
- Anderson Valdiney Gomes Ramos (ORCID: https://orcid.org/0000-0001-9863-018X)
- Mary Ann Foglio (ORCID: https://orcid.org/0000-0001-7715-4452)
- Débora Cristina Baldoqui (ORCID: https://orcid.org/0000-0002-5824-8573)
- Solange Maria Cottica (ORCID: https://orcid.org/0000-0003-3183-2531)
- Ana Lúcia Tasca Góis Ruiz (ORCID: https://orcid.org/0000-0002-0844-8702)
- Helena Mannochio-Russo (ORCID: https://orcid.org/0000-0002-4961-2353)
- Marta Regina Barrotto do Carmo (ORCID: https://orcid.org/0000-0002-4426-0029)
- Maria Helena Sarragiotto (ORCID: https://orcid.org/0000-0002-4266-0651)
- Yasmin Rodrigues Chierici
Institutions
- Universidade Estadual de Maringá (BR)
- Universidade Tecnológica Federal do Paraná (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of California San Diego (US)
- Instituto de Ciências Farmacêuticas (BR)
- University of Montana (US)
- Universidade Estadual de Ponta Grossa (BR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1002/cbdv.202402696
- Citations
- 1
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico