Florfenicol-induced dysbiosis impairs intestinal homeostasis and host immune system in laying hens
The uncontrolled and widespread use of florfenicol can negatively affect intestinal health in chickens. Specifically, florfenicol was found to impair intestinal homeostasis and immune function in laying hens, including by reducing butyrate levels, thereby increasing their susceptibility to systemic APEC infection. The development of strategies for mitigating the adverse effects of florfenicol on gut health and pathogen susceptibility in laying hens is therefore essential.
Authors
- Sohyoung Won (ORCID: https://orcid.org/0000-0003-2039-6017)
- Tina Sørensen Dalgaard (ORCID: https://orcid.org/0000-0002-3424-6047)
- Keesun Yu (ORCID: https://orcid.org/0000-0002-7596-1987)
- Young Jin Pyung (ORCID: https://orcid.org/0000-0001-8313-8475)
- Byung-Chul Park
- Tae Sub Park (ORCID: https://orcid.org/0000-0002-0372-5467)
- Seung Hyun Han (ORCID: https://orcid.org/0000-0002-8180-2915)
- Younghoon Kim (ORCID: https://orcid.org/0000-0001-6769-0657)
- Minseong Kim (ORCID: https://orcid.org/0000-0003-1743-9717)
- Inhwan Choi (ORCID: https://orcid.org/0000-0002-0141-6329)
- Jin-Sun Lee (ORCID: https://orcid.org/0000-0002-2550-0883)
- Cheol‐Heui Yun (ORCID: https://orcid.org/0000-0002-0041-2887)
- Youbin Choi
Institutions
- Seoul National University (KR)
- Aarhus University (DK)
- National Institute of Agricultural Science and Technology (KR)
- National University College (PR)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s40104-025-01186-w
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Research Foundation
- Seoul National University
- Ministry of Science and ICT, South Korea