Hydroxychloroquine cures autoimmune myocarditis by inhibiting the innate immune system via the C‐X‐C motif chemokine ligand 16 and C‐X‐C motif receptor 6 axis between macrophages and T cells
HCQ improves cardiac function and reduces inflammation in myocarditis by inhibiting CXCL16 expression in macrophages, by suppressing its transcription factor YY1, which in turn reduced the chemotaxis of Th17 and NKT cells. HCQ is a promising therapeutic agent for myocarditis.
Authors
- Minyu Liao
- Dao Wen Wang (ORCID: https://orcid.org/0000-0002-9774-3980)
- Xu Gao (ORCID: https://orcid.org/0000-0002-3542-3439)
- Yunling Xuan (ORCID: https://orcid.org/0000-0001-9969-9795)
- Huihui Li (ORCID: https://orcid.org/0000-0003-0511-1693)
- Jin Wang (ORCID: https://orcid.org/0000-0002-0062-2489)
- Zhou Zhou (ORCID: https://orcid.org/0000-0002-6259-9106)
- Wen Zheng (ORCID: https://orcid.org/0000-0003-4931-6615)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1111/bph.70028
- Citations
- 6
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.33
Funders
- National Natural Science Foundation of China