Effects of Methylenetetrahydrofolate Reductase Polymorphism on Clinical Features of High-Risk Psychosis Before Schizophrenia
Increased MTHFR polymorphism was associated with the risk progression of schizophrenia, being more pronounced in males than in females. Higher amounts of hypofunctional MTHFR variants tended to decrease the cognitive ability in both high-risk and healthy subjects, while higher risk levels are observed in CHR subjects.
Authors
- Xueqing Han
- Lin Wan (ORCID: https://orcid.org/0009-0007-4317-3736)
Institutions
- Beijing Tongren Hospital (CN)
Publication Details
- Journal
- Psychiatry Investigation
- Published
- 2025-04-14
- DOI
- https://doi.org/10.30773/pi.2024.0379
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation