The role of chronic tonsillitis in the recurrent pregnancy loss of immune origin

The prevalence of chronic tonsillitis (CT) varies from 5 to 12%. Against the background of CT, a large number of disorders are formed, including in the reproductive system. Among the problems of practical obstetrics, spontaneous miscarriages account for 10 to 20% of cases. Unexplained reproductive losses can have immunological causes including those associated with CT. Approximately 20% of women with recurrent pregnancy loss (RPL) have elevated serum levels of autoantibodies with a predominant predominance of antiphospholipid antibodies (APLA). There is a neuro-reflex mechanism of the influence of CT on the formation of associated pathology. The afferent connections of the palatine tonsils with the most important subcortical formations, in particular with the structures of the posterior subcortical region of the hypothalamus, have been studied – they are the first to react to antigens. Infectious agents play a key role in the genesis of APLA formation, since they have molecular mimicry. The molecular mimicry of bacteria and viruses in relation to anti-β2HP1 is the main mechanism by which pathogens induce the synthesis of these antibodies in genetically predisposed patients. The palatine tonsils play an important role in initiating an immune response against antigens. It should be recognized that the condition of the palatine tonsils in patients with immunological causes of infertility is underestimated in modern clinical practice.