Biomarkers of ocular manifestation in newly diagnosed giant cell arteritis
OCT and OCTA imaging revealed structural and perfusion alterations in newly diagnosed GCA patients. Retinal microcirculation was altered, even regardless of the presence of ophthalmic symptoms. Structural changes correlated with systemic manifestations of GCA, suggesting a link between extracranial and intracranial involvement. Our findings underscore the potential diagnostic value of OCT and OCTA biomarkers for ocular involvement in GCA.
Authors
- Valentin Sebastian Schäfer (ORCID: https://orcid.org/0000-0002-6591-5936)
- Frank Gerhard Holz (ORCID: https://orcid.org/0000-0001-8019-9272)
- Lara C Burg (ORCID: https://orcid.org/0000-0002-5379-9149)
- Leon von der Emde (ORCID: https://orcid.org/0009-0009-2630-3732)
- Katharina Reinking
- Simon Michael Petzinna (ORCID: https://orcid.org/0000-0002-4686-1143)
- Charlotte Behning (ORCID: https://orcid.org/0000-0002-9310-3804)
- Jan Henrik Terheyden (ORCID: https://orcid.org/0000-0002-0174-4066)
- Robert Patrick Finger (ORCID: https://orcid.org/0000-0003-4253-7597)
- Maximilian W. M. Wintergerst (ORCID: https://orcid.org/0000-0002-2766-7038)
- Julie Jungblut
- Thomas Ach
Institutions
- University of Bonn (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospital Heidelberg (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1186/s12886-025-03997-x
- Citations
- 3
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.56