MFGE8 regulates the EndoMT of HLMECs through the BMP signaling pathway and fibrosis in acute lung injury
MFGE8 regulates LPS-induced EndoMT in HLMECs via the BMP/Smad1/5-Smad4 pathway and protects against pulmonary fibrosis in acute lung injury, suggesting it as a therapeutic target for ALI and ARDS.
Authors
- Daoxin Wang (ORCID: https://orcid.org/0000-0001-8327-3650)
- Qing-Qiang Shi
- Hanghang Wang (ORCID: https://orcid.org/0000-0002-9432-0261)
- Huang Liu (ORCID: https://orcid.org/0000-0001-8889-9054)
- Di Qi (ORCID: https://orcid.org/0000-0002-8267-9832)
- Ling Tang (ORCID: https://orcid.org/0000-0002-2793-7843)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1186/s12931-025-03215-8
- Citations
- 3
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.39