Activity of imipenem/relebactam against KPC-producing Klebsiella pneumoniae and the possible role of Ompk36 mutation in determining resistance: an Italian retrospective analysis
IMI/REL showed good in vitro activity against the KPC-Kp strains analysed. All the IMI/REL-resistant strains displayed a mutation in porin OmpK36 and produced carbapenemases, with KPC-2 and KPC-3 being equally distributed. MVB and CZA maintained good activity against IMI/REL resistant isolates.
Authors
- Chiara Vismara
- Federico Di Marco (ORCID: https://orcid.org/0000-0003-0376-1342)
- Agnese Comelli (ORCID: https://orcid.org/0000-0003-4817-8337)
- Elisa Matarazzo
- Alessandra Bielli (ORCID: https://orcid.org/0000-0002-6314-279X)
- Francesca Saluzzo (ORCID: https://orcid.org/0000-0001-6705-1716)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0001-9440-4601)
- Antonio Muscatello (ORCID: https://orcid.org/0000-0002-2428-6432)
- Emanuele Palomba (ORCID: https://orcid.org/0000-0003-1386-6180)
- Marianna Rossi (ORCID: https://orcid.org/0000-0001-9443-3306)
- Daniela María Cirillo (ORCID: https://orcid.org/0000-0001-6415-1535)
- Noemi Lo Re
- Andrea Gori (ORCID: https://orcid.org/0000-0001-6587-4794)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- Luigi Sacco Hospital (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Centre for Multidisciplinary Research in Health Science (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1186/s12941-025-00792-w
- Citations
- 7
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 4.14
Funders
- Università degli Studi di Milano
- European Society of Clinical Microbiology and Infectious Diseases
- Università degli Studi dell'Insubria
- Università degli Studi di Brescia
- MSD Italia