The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8
Indisulam is a promising therapeutic candidate for AMKL and the RBM39-mediated ZMYND8 splicing plays an important role in promoting the development of AMKL.
Authors
- Yixin Hu (ORCID: https://orcid.org/0000-0001-9392-8016)
- Fenli Zhang
- Xiaoyan Yang (ORCID: https://orcid.org/0000-0003-3086-0792)
- Lei Shi (ORCID: https://orcid.org/0000-0001-9100-897X)
- Yumeng Wu (ORCID: https://orcid.org/0000-0001-7648-365X)
- Ailian Guo
- FJ Yao
- Shaoyan Hu (ORCID: https://orcid.org/0000-0003-1285-9499)
- Jian Pan (ORCID: https://orcid.org/0000-0002-0292-5141)
- Zhongling Wei (ORCID: https://orcid.org/0000-0002-2763-0964)
- Wanyan Jiao
- Yizhen Li (ORCID: https://orcid.org/0000-0002-0762-7899)
- Yi‐Jun Wu (ORCID: https://orcid.org/0000-0003-1064-2886)
- Yang Yang (ORCID: https://orcid.org/0000-0002-0273-9242)
- Chunxia Yang
- Li Gao (ORCID: https://orcid.org/0000-0003-4418-0528)
- Yongping Zhang (ORCID: https://orcid.org/0000-0001-5090-9173)
- Yan Li
- Zhixu He (ORCID: https://orcid.org/0000-0002-8263-129X)
- Ying Yang (ORCID: https://orcid.org/0000-0002-6304-601X)
- Bi Zhou (ORCID: https://orcid.org/0000-0002-8943-845X)
- Yanfang Tao
- Juanjuan Yu
- Zimu Zhang (ORCID: https://orcid.org/0000-0003-0415-9425)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0001-7114-8780)
- Zhiheng Li (ORCID: https://orcid.org/0000-0002-2977-2624)
- Junjie Fan
- Tongting Ji
- Di Wu (ORCID: https://orcid.org/0000-0002-8452-6282)
- Peifang Xiao (ORCID: https://orcid.org/0000-0002-8237-7930)
Institutions
- Guiyang Medical University (CN)
- China Pharmaceutical University (CN)
- Bengbu Medical College (CN)
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Suzhou Guangji Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Suzhou Vocational Health College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1186/s13578-025-01380-3
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China