Stereoisomerism in Trimacrocyclic Structures Fused by a Pillar[6]arene and Two [8]Cycloparaphenylenes

Stereoisomerism in pillararenes, particularly chiral isomerism from atropisomers, has intrigued organic chemists. Herein, we report the synthesis and characterization of a trimacrocyclic system formed by fusing two [8]cycloparaphenylenes with a pillar[6]arene. This system exhibits unique stereoisomerism, yielding a racemic mixture and a <i>meso</i> compound. The isomers were characterized using NMR, HRMS, and single crystal X-ray diffraction. This study offers valuable insights into constructing chiral isomers in macrocycles and enriches our understanding of stereochemistry.