Germline variants in patients from the Iranian hereditary colorectal cancer registry

The study identified crucial germline variants for hereditary polyposis and non-polyposis CRC pathogenesis in the Iranian population. A selective strategy and cascade genetic testing are recommended for the diagnosis of hereditary colorectal cancer syndromes.

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Publication Details

Journal
Cancer Cell International
Published
2025-04-13
DOI
https://doi.org/10.1186/s12935-025-03773-3
Citations
5
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
7.36

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article

Germline variants in patients from the Iranian hereditary colorectal cancer registry

Ali Javadmanesh, Hans F. A. Vasen, Hesam Dehghani, Fatemeh Maghool et al.
5 citations
Cancer Cell International
Genetic factors in colorectal cancer
7.36
article

Germline variants in patients from the Iranian hereditary colorectal cancer registry

Ali Javadmanesh, Hans F. A. Vasen, Hesam Dehghani, Fatemeh Maghool, Ashkan Torshizian, Saeed Hoorang, Mohammad Hassan Emami, Alireza Bary, Lena Goshayeshi, Benyamin Hoseini, Foroogh Alborzi Avanaki, Milad Shademan, Mehrdad Zeinalian, Farnood Rajabzadeh, Ladan Goshayeshi, Massih Bahar, Mohammad Reza Keramati, Maliheh Alimardani, Hassan Vosoghinia, Mohammad Reza Abbaszadegan, Nasser Ebrahimi Daryani, Morteza Zahedi, Jamshid Sorouri-Khorashad, Maryam Afrazeh
article en
5 citations

Abstract

The study identified crucial germline variants for hereditary polyposis and non-polyposis CRC pathogenesis in the Iranian population. A selective strategy and cascade genetic testing are recommended for the diagnosis of hereditary colorectal cancer syndromes.

Cancer Cell InternationalVol. 25(1)
Isfahan University of Medical Sciences (IR), University of Neyshabur (IR), Mashhad University of Medical Sciences (IR), Islamic Azad University, Mashhad (IR), Leiden University Medical Center (NL), Sina Hospital (IR), Royal Marsden Hospital (GB), Motamed Cancer Institute (IR), Imam Reza Hospital (IR), Tehran University of Medical Sciences (IR), Ferdowsi University of Mashhad (IR)
Ferdowsi University of Mashhad, Mashhad University of Medical Sciences, National Institute for Medical Research Development
Good health and well-being
Openalex Percentile: Top 3%
Genetic factors in colorectal cancer
7.36
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