Germline variants in patients from the Iranian hereditary colorectal cancer registry
The study identified crucial germline variants for hereditary polyposis and non-polyposis CRC pathogenesis in the Iranian population. A selective strategy and cascade genetic testing are recommended for the diagnosis of hereditary colorectal cancer syndromes.
Authors
- Ali Javadmanesh (ORCID: https://orcid.org/0000-0001-6016-5905)
- Hans F. A. Vasen (ORCID: https://orcid.org/0000-0003-2682-2603)
- Hesam Dehghani (ORCID: https://orcid.org/0000-0001-6750-0040)
- Fatemeh Maghool (ORCID: https://orcid.org/0000-0002-0845-4600)
- Ashkan Torshizian (ORCID: https://orcid.org/0000-0002-5798-7737)
- Saeed Hoorang (ORCID: https://orcid.org/0000-0001-5483-5204)
- Mohammad Hassan Emami
- Alireza Bary
- Lena Goshayeshi (ORCID: https://orcid.org/0000-0002-5969-5359)
- Benyamin Hoseini (ORCID: https://orcid.org/0000-0002-0355-6181)
- Foroogh Alborzi Avanaki (ORCID: https://orcid.org/0000-0002-5248-6546)
- Milad Shademan (ORCID: https://orcid.org/0000-0003-2248-7959)
- Mehrdad Zeinalian (ORCID: https://orcid.org/0000-0003-1381-0582)
- Farnood Rajabzadeh (ORCID: https://orcid.org/0000-0001-6581-4716)
- Ladan Goshayeshi (ORCID: https://orcid.org/0000-0002-4184-8353)
- Massih Bahar
- Mohammad Reza Keramati (ORCID: https://orcid.org/0000-0003-0099-7114)
- Maliheh Alimardani (ORCID: https://orcid.org/0009-0001-1310-4234)
- Hassan Vosoghinia
- Mohammad Reza Abbaszadegan
- Nasser Ebrahimi Daryani
- Morteza Zahedi
- Jamshid Sorouri-Khorashad
- Maryam Afrazeh
Institutions
- Isfahan University of Medical Sciences (IR)
- University of Neyshabur (IR)
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
- Leiden University Medical Center (NL)
- Sina Hospital (IR)
- Royal Marsden Hospital (GB)
- Motamed Cancer Institute (IR)
- Imam Reza Hospital (IR)
- Tehran University of Medical Sciences (IR)
- Ferdowsi University of Mashhad (IR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1186/s12935-025-03773-3
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Ferdowsi University of Mashhad
- Mashhad University of Medical Sciences
- National Institute for Medical Research Development