STUDY OF THE ACUTE TOXICITY OF A NASAL SPRAY BASED ON ANTIGENS OF OPPORTUNISTIC BACTERIA

The article presents the results of determining the acute toxicity of a nasal spray based on antigens of opportunistic bacteria in two formulations: with and without a prolonging agent. According to the Hodge and Sterner toxicity classification, when administered to mice at the maximum possible doses, the formulations were classified as up to class 4 toxicity for subcutaneous administration and up to class 3 toxicity for intranasal administration. These findings support the feasibility of further development of the formulations.