Formulation & Evalution of Anti Fungal gel using Datura Stramonium

In order to fight Candida albicans, a common fungal pathogen that causes a variety of illnesses, including oral and vaginal candidiasis, this study focusses on creating and testing an antifungal herbal gel with Datura stramonium extracts as the active ingredient. Alkaloids with antibacterial and antifungal qualities, including atropine, scopolamine, and hyoscyamine, are found in the plant Datura stramonium, which is well-known for its therapeutic uses. These bioactive substances will be extracted from the plant's leaves and added to a gel formulation as part of the experiment. By using techniques like Minimum Inhibitory Concentration (MIC) determination and antifungal activity assays, the gel's efficacy will be assessed based on its capacity to stop Candida albicans growth in vitro. Utilising Datura stramonium's inherent qualities for its possible medicinal use, the gel aims to offer a topical, simple-to-apply substitute for treating fungal infections. In order to guarantee the gel's safety and effectiveness as a topical antifungal treatment, the study also evaluates the gel's stability, pH, and risk for skin irritation. The project's overall goal is to provide a plant-based, sustainable treatment alternative with fewer adverse effects than traditional antifungal medications.